Growth Hormone Inhibits Renotropic Action of Luteinizing Hormone-Isoform(s).
نویسندگان
چکیده
منابع مشابه
Luteinizing hormone-releasing hormone antagonists.
BACKGROUND Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. OBJECTIVE/METHOD Here we give an overview of the most r...
متن کاملThe renotropic effect of ovine luteinizing hormone on subtotally nephrectomized rats.
Some of luteinizing hormone (LH) isoforms can stimulate renal growth. The objective of this study is to determine whether the administration of LH modifies subtotal nephrectomy-induced chronic renal failure. Castrated 3/4-nephrectomized male rats were divided into four groups of seven each and fed a low-protein (6%) diet. Ovine LH with renotropic activity (40 micrograms/day) or vehicle only (co...
متن کاملLuteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone.
The ability of luteinizing hormone-releasing hormone (LHRH) neurons to express the oncogene c-fos was examined during the estrous cycle in rats. The immunocytochemical localization of the c-fos-encoded antigen, Fos, was coupled with the immunocytochemical localization of LHRH. LHRH neurons showed no Fos immunoreactivity during diestrus-1, diestrus-2, estrus, or the morning of proestrus. However...
متن کاملPurine amplification of luteinizing hormone action in ovarian luteal cells.
Adenosine produced a severalfold amplification of luteinizing hormone (LH)-stimulated cAMP accumulation and progesterone secretion in rat luteal cells, but showed no similar effect on LH-stimulated cAMP accumulation and androgen secretion in Leydig cells. In the absence of LH, adenosine produced a small but significant stimulation of cAMP accumulation and steroid secretion in both luteal and Le...
متن کاملMechanism of action of gonadotropin-releasing hormone. Involvement of phospholipid turnover in luteinizing hormone release.
The action of gonadotropin-releasing hormone (GnRH) upon luteinizing hormone (LH) secretion is calcium-dependent, but is not mediated by cyclic AMP, cyclic GMP, or prostaglandins. The role of calcium-mediated phospholipid turnover in GnRH action was investigated in 2-day cultured pituitary cells, in which the production and target cell effects of arachidonic acid were analyzed in relation to Gn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1988
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.35.413